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Multifunctional nanoparticles have a wide range of applications in the early diagnosis and treatment of cancer. Recently, Wang Zhenxin, the State Key Laboratory of Electroanalytical Chemistry of the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, has developed a simple and effective method for preparing multi-functional nanocomplexes for diagnosis and treatment.
The research of the research group shows that the hydrophobic micronanoparticles can be coated with a biocompatible polydopamine nanoshell by reverse microemulsion method. The introduction of polydopamine shell not only improves the hydrophilicity of nanoparticles. Sexual and biocompatibility can also enable nanocomposites to have both photothermic and chemotherapeutic capabilities by adsorbing chemotherapeutic drugs such as doxorubicin.
Due to its unique optical, magnetic, and CT properties, rare earth nanoparticles have given multimodality imaging capabilities to composites, including UCL (upconversion fluorescence imaging), MRI (magnetic resonance imaging), and CT (computed tomography imaging). . In vitro and in vivo tests have shown that this nanocomposite not only has good multimodality imaging imaging capabilities, but also can effectively kill cancer cells through the synergy of photothermal and chemotherapy to obtain better therapeutic effect. In addition, this reverse microemulsion coating method is expected to expand to other hydrophobic nanoparticles for the construction of multifunctional nanoparticles. Related work was published on Adv. Healthc. Mater. 2015, 4, 559, and was selected as the cover of the current issue.
In addition, the research group also conducted a series of research work on the water-soluble modification of rare earth inorganic nanoparticles and the preparation of composite structures, and they were published in Nanoscale 2013, 5, 1047, Biomaterials 2013, 34, 5218 and Small 2015, doi: 10.1002/smll.201500287. The above work was funded by the National Natural Science Foundation and the "973" program.
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